Intestinal Stem Cells:

Bohin, N., T.M. Keeley, A.J. Carulli, E.M. Walker, E.A. Carlson, J. Gao, I. Aifantis, C.W. Siebel, M.W. Rajala, M.G. Myers, Jr., J.C. Jones, C.D. Brindley, P.J. Dempsey, L.C. Samuelson. Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition. Stem Cell Reports (in press, 2020).

Bohin, N., K.P. McGowan, T.M. Keeley, E.A. Carlson, K.S. Yan, L.C. Samuelson. Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response after Irradiation Injury. Cell. Mol. Gastroenterol. Hepatol. (in press, 2020).

Bohin, N., E.A. Carlson, L.C. Samuelson. Genome toxicity and impaired stem cell function after conditional activation of CreER^T2 in the intestine. Stem Cell Reports 11:1337-1346 (2018). PMCID: PMC6294112.

Carulli, A.J., T.M. Keeley, E.S. Demitrack, J. Chung, I. Maillard, L.C. Samuelson. Notch Receptor Regulation of Intestinal Stem Cell Homeostasis and Crypt Regeneration. Dev. Biol. 402:98-108 (2015). PMCID: PMC4433599

VanDussen, K.L., A. J. Carulli, T.M. Keeley, S.R. Patel, B.J. Puthoff, S.T. Magness, I.T. Tran, I. Mallard, C. Siebel, A. Kolterud, A. Grosse, D.L. Gumucio, S.A. Ernst, Y-H Tsai, P. Dempsey and L.C. Samuelson. Notch Signaling Modulates Proliferation and Differentiation of Intestinal Crypt Base Columnar Stem Cells. Development 139:488-497 (2012). PMCID: PMC3252352

Bohin, N., T.M. Keeley, A.J. Carulli, E.M. Walker, E.A. Carlson, J. Gao, I. Aifantis, C.W. Siebel, M.W. Rajala, M.G. Myers, Jr., J.C. Jones, C.D. Brindley, P.J. Dempsey, L.C. Samuelson. Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition. StemCell Reports 15:156-170 (2020). PMCID: PMC7363878.

Bohin, N., K.P. McGowan, T.M. Keeley, E.A. Carlson, K.S. Yan, L.C. Samuelson. Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response after Irradiation Injury. Cell. Mol. Gastroenterol. Hepatol. 10:797-810 (2020). PMCID: PMC7502577. Accompanying editorial: Lengner, C.J. mTORC1 at the Crossroads of Facultative Intestinal Stem Cell Activation. Cell. Mol. Gastroenterol. Hepatol. 10:857-858 (2020).

Gastric Stem Cells:

Hibdon, E.S., N. Razumilava, T.M. Keeley, G. Wong, S. Solanki, Y.M. Shah, L.C. Samuelson. Notch and mTOR signaling pathways promote human gastric cancer cell proliferation. Neoplasia 21:702-712 (2019). PMCID: PMC6536707.

Keeley, T.M., N. Horita, L.C. Samuelson. Tamoxifen-Induced Gastric Injury: Effects of Dose and Method of Administration. Cell. Mol. Gastroenterol. Hepatol. 8:365-67 (2019). PMCID: PMC6713893.

Gifford, G.B., E.S. Demitrack, T.M. Keeley, A. Tam, N. LaCunza, P.H. Didhia, J.R. Spence, D.M. Simeone, I. Saotome, A. Louvi, C.W. Siebel, L.C. Samuelson. Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homeostasis. Gut. 66:1001-1011 (2017). PMCID: PMC5009003

Demitrack, E.S., G.B. Gifford, A.J. Carulli, T.M. Keeley, K.L. VanDussen, D. Thomas, T. Giordano, Z. Liu, R. Kopan and L.C. Samuelson. Notch Signaling Regulates Gastric Antral LGR5 Stem Cell Function. EMBO J 34:2522-36 (2015). PMCID: PMC4609184

Horita, N., T.M. Keeley, E.S. Hibdon, E. Delgado, D. Lafkas, C.W. Siebel, L.C. Samuelson. Delta-like1-expressing cells at the antral gland base promote proliferation of gastric stem cells in mouse.Cell Mol Gastroenterol Hepatol 13:275-287 (2021). PMCID: PMC8599166.

Reviews and Commentaries:

Samuelson, L.C. News and Views: Intestinal Niche Conundrum Solved. Nature 558:380-381(2018).

Demitrack, E.S., L.C. Samuelson. Notch Regulation of Gastrointestinal Stem Cells. J. Physiol. 594:4791-803. doi: 10.1113/JP271667 (2016). PMCID: PMC5009795

Razumilava Lab Publications

Zaki, N.H.M., J, Shiota, L.C. Samuelson, T.M. Keeley, A.N. Calder, K. Nakao, N. Razumilava. CXCL1 is regulated by Hedgehog signaling to induce extrahepatic bile duct repair after acute injury. Hepatology (2022 in press)

Shiota, J., L.C. Samuelson, N. Razumilava. Hepatobiliary organoids and their applications for studies of liver health and disease: are we there yet? Hepatology 74:2251-2263 (2021).